Adult Surgery

Obese Patients With Knee Osteoarthritis Benefit From Knee Replacement Surgery

Gina Gagua

July 31, 2008

After total knee arthroplasty (TKA) for osteoarthritis of the knee, obese patients fare nearly as well as their normal-weight peers, a British research team reports in the July 24 online issue of the Annals of the Rheumatic Diseases.

"At least one National Health Service trust in the UK has been reported to apply a policy that TKA should not be offered to patients with a body mass index (BMI) > 30 kg/m," Dr. Cyrus Cooper, at the University of Southampton, and associates write. "However, it does not necessarily follow that patients who are obese will benefit less from TKA than others."

The investigators' original study included patients aged 45 years and older who were placed on a waiting list for TKA because of primary knee osteoarthritis from 1995 to 1997, and a control group selected from the general population matched for age, sex, and general practice.

To ascertain long-term outcomes, Dr. Cooper's group recontacted 325 surgical cases approximately 6 years later (range 2-8 years) and 363 nonsurgical control subjects. Average age at follow-up was 70 years.

At baseline, physical function was markedly worse in the patient group than in the controls (mean score 20 vs 89, p < 0.001). However, at follow-up, physical function scores had improved by 6 points, while that of controls had worsened by 14 points (p < 0.001).

In the subgroup of subjects with baseline BMI > 30, median physical function score increased by 3 points among the 108 patients, while deteriorating by 36 points among the 36 controls.

Dr. Cooper's team also evaluated outcomes among subjects who were older than 75 years at baseline. Physical function scores were unchanged at follow-up among 82 patients, whereas there was a substantial decline of 40 points among the 87 controls.

"TKA halts the decline and maintains physical function up to the oldest age groups," they conclude.

Improvement in physical function following surgery tended to be superior in those with more severe radiological changes in the knee, and worse in those with pain in other joints.

"Higher BMI should not be a contraindication to TKA," Dr. Cooper and his group advise, "provided that the patient is sufficiently fit to undergo the short-term rigours of surgery."

Ann Rheum Dis 2008.

Reviewed by Ramaz Mitaishvili, MD

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