Merck’s Gardasil Not Cleared for Older Women

U.S. regulators have told Merck & Co they cannot yet approve Merck's application to expand marketing of its HPV vaccine Gardasil to an older group of women, the drugmaker said Wednesday.

Blood Substitute Safely Reduces Need for Transfusion Following Elective Surgery

A hemoglobin-based oxygen carrier (HBOC-201, Biopure Corporation) appears to be a safe substitute for blood transfusion, according to results of a multinational, phase III clinical trial among patients undergoing elective orthopedic surgery. However, the blood substitute may not be appropriate for high-risk patients and patients over the age of 80, the findings suggest.

Universal Truths Abide in Medicine, Even in Parallel Universes

Medicine is practiced differently around the world, and yet some aspects — especially the frustrations — are fairly universal. Where better can you experience the similarities and differences than in the blogging world, where clinicians share stories from their practices and their personal lives? Two physician bloggers, known as "Dr. Dino" and "Dr. Emer," provide […]

VA Study: ART Confers Negligible Risk for Heart Disease

Four-year follow-up of more than 40,000 HIV-infected patients revealed no association between longer durations of ART exposure and risk for cardiovascular disease. Summary Many antiretroviral regimens have been associated with metabolic perturbations that are linked to risk for atherosclerotic heart disease. Consequently, there is keen interest in determining the rates of cardiovascular events among HIV-infected […]

Post-Myocardial Infarction Cardiogenic Shock: What’s New?

Cardiogenic Shock: Current Concepts and Improving OutcomesReynolds HR, Hochman JSCirculation. 2008;117:686-697 Cardiogenic Shock: Basics and Clinical ConsiderationsGowda RM, Fox JT, Khan IA Int J Cardiol. 2008;123:221-228 Historically, cardiogenic shock (CS) was nearly always fatal after myocardial infarction (MI). Mortality rates were consistently reported at approximately 80% until the 1990s, when the mortality improved but only […]

The Case of the Ruthless Ruler With a Deadly Disease

Introduction The patient was an elderly male, a member of a prominent royal family, who became a ruthless ruler of a European principality. Little is known about his medical background, family history, or details about his final illness except that he was obese and a nonsmoker. From what is now known about his cause of […]

Annual FIT Testing Detects Colorectal Cancer Two Years Earlier Than Colonoscopy Alone

Annual FIT Testing Detects Colorectal Cancer Two Years Earlier Than Colonoscopy Alone, Study of High-Risk Population Finds SAN DIEGO, May 20 /PRNewswire-FirstCall/ — An interim analysis of a study presented today at the 39th Annual Digestive Disease Week (DDW) Conference found that, among patients at increased risk for colorectal cancer who completed an annual fecal […]